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Detectives Nate Sowa and Ray Diaz take on the investigation of a missing person case that may turn out to be a homicide. A witness reported seeing a 25-year-old male brutally beaten, and that same male has not been seen for days. Without a body, how do you prove murder? Two brothers are suspected of the beating, but Sowa and Diaz must determine if they committed a murder--so it's a race against time to find the victim alive, or find proof of his death. It will take cutting edge forensics to solve this case, and if the evidence doesn't add up, someone may be getting away with murder.

At a Latin club, a man dances the night away with a pretty woman, then watches her take to the floor with a younger guy. A witness claims to observe the older man gun down the younger man then speed away. Detectives Ed Brickley and Randall Cook follow the trail of the suspect based on the witness's description. But as they peel back the layers of the investigation, they realize they've been led astray. With the help of a confidential informant and forensic tools like ballistic analysis the detectives plan a dangerous stakeout to stop the real killer before he strikes again.

In a quiet Indianapolis suburb, two men are found fatally beaten in their bedrooms. Detective Bobby Flack is called to the scene and quickly learns that the victims had been harassed for being gay. Were these murders a hate crime? Could the killer be a neighbor living in this picturesque suburb? Or, is he a master manipulator leading the detectives on a wild goose hunt in order to conceal his true identity? The search for the truth takes Flack on a journey into the mind of a twisted killer and culminates in a dramatic nationwide manhunt for the suspect's arrest.

Hours into her first shift, Investigator Cathy Lucci meets partner Dave Salvatore at the scene of her first homicide case. A 49-year-old male has been brutally stabbed and left to die with a blanket covering him. Investigators question anyone who knew the victim. There are a few suspects and many questions. But who was angry enough to stab a man 46 times and concerned enough to cover him with a blanket? With no clear answers, Lucci's first case is a complicated puzzle. Can she and Salvatore put the pieces together?

Detectives Tim Entenok and Tom Armelli are called to the scene of a grizzly family shooting. Two adults and three young children have been killed. Detectives work their way through spent bullets, shell casings, and other evidence at the scene, including two firearms, to piece together what happened and discover what led to this violent family massacre. Was it the result of a home invasion or a domestic dispute? And where is the missing upstairs neighbor? Detectives send all available officers into the dark night to find a violent, brutal killer before he can cause more devastation.

On the morning of July 5th, the body of the victim is found lying face up in an abandoned lot that had been used to shoot off guns the night before in celebration of Independence Day. More than 60+ shell casings are collected from the crime scene, which detectives hope will include an essential clue. A tip leads detectives to a possible suspect, who denies any involvement in the killing, although his polygraph may show otherwise. Detectives search his girlfriend's house for other evidence. Meanwhile, rumor on the street is that a high-level dealer was actually the shooter. As their list of suspects grows, the case quickly evolves into what seems to be a conspiracy -- but without an on-the-record eyewitness, Detective Simms won't be able to prove the case.

Informational programming.

Informational programming.

Informational programming.

Informational programming.

When two female college students are murdered, police suspect Rex Allen Krebs, who had been jailed for attacking and raping women in their homes 11 years earlier. The case ultimately brings into question the California penal system's treatment of sexual predators.

When a New Jersey woman is murdered on her wedding day by her ex-boyfriend, the case stirs a heated debate about the nature of crimes of passion.

Sgt. Robert Jaworski and Det. Cliff Porter try to break down a stabbing suspect's story; Detectives Shannon Lucy and R. J. Wilson get a shocking confession when they interrogate a murder suspect; and Porter plays two robbery suspects against each other.

Cold case detective Eddie Majors has been investigating the shooting death of a 19-year-old man for six years, but he finally thinks he has his man; Detectives R. J. Wilson and Shannon Lucy try to bluff a suspect, but he turns the tables and tries to fool them by playing insane; and Det. Mark Kennedy and Cpl. Christopher Stout grill the girlfriend of a man who was stabbed to death.

When a man is burned to death, Det. Jeff Felton and Sgt. Mike Huff interrogate the dead man's on-again-off-again girlfriend and her lover; and emotions run high when Detectives Cliff Porter, Ken Larsen, and Jeff Nohr question a suspect in the murder of a teenage girl.

Sgt. Mike Huff finally has a suspect in a murder he's been investigating for seven years, but now he must close the case in the interrogation room; Huff and Detectives Jeff Felton and Victor Regalado put a murder suspect through five hours of grueling questioning; and Regalado uses his memory of a justified shooting earlier in his police career to try to break down a murder suspect.

After a mother and her two sons are killed, Det. Mike Nance and Sgt. Mike Huff interrogate their chief suspect, who turns out to be one of the murdered boys' best friend. And after a man is found shot to death on the sidewalk, Detectives Dennis Redner and Bill Martino must crack their suspect's tough shell to solve the case.

For the men and women on the Nightwatch, two things never stop: the calls and the questions. How can someone shoot an eight-year-old boy? How do you stop the drug epidemic in the worst parts of New Orleans? How do you get guns off the city streets? As the first responders do everything they can do save the victims of several shootings, a drug overdose, and more; and the police officers chase suspects who end up having illegal firearms, they find themselves asking these questions--and only wishing they had the answers.

The best people on the job never stop looking for ways to do more and be better. For police officer Justin, the objective is joining the force's SWAT team, and he takes a big step by leading a raid with the SWAT officers. Meanwhile, the first responders deal with a rash of scary calls, including a man suffering from amnesia after getting hit by a car, and a woman who fell off a roof. And after a man survives a suicide attempt, Arkady forges a bond with him by sharing the story of her mother's own suicide.

Like any dad, Titus wants the best for his son. As an EMT, he sees just how dire life can get. From drug addicts desperate to kick their problems, to assault victims, to a teenager who drove his car into a tree, nights in New Orleans reveal the struggles of life in this city. Meanwhile, police officers continue to work desperately to get guns off the street--and make the city a safer place to live.

On the tenth anniversary of Hurricane Katrina, everyone in New Orleans and on the Nightwatch recall their experiences with the storm, and reflect upon the significance it still holds in their lives. But amid the remembrances, the city still needs its first responders. And over the course of a busy run of calls for the EMT's, the police SWAT team looks to execute a high-risk raid. The people on the Nightwatch will do anything to protect their city.

Every night, every shift offers its own adventures and its own unforgettable New Orleans characters to help and protect. And on this special episode of Nightwatch, we revisit the most memorable police, fire and EMS cases from the past 20 episodes. With, shocking revelations, never-seen-before footage, and the New Orleans first responders that you have come to love.

The team celebrates the opening of its new headquarters, finally complete after 10 years of working out of trailers. Meanwhile, Titus has his own new beginning as he's received his paramedic's license and he and long-time partner Dan must adjust to their new shared roles in a variety of calls. And the new team, Arcady and Ted, get to know each other's styles in their first shifts together.

In a night filled with multiple shootings, Holly and Nick have to search for a gunshot victim that has gone missing. Meanwhile Titus and Dan tend to a man stabbed multiple times. Keeley is heartbroken about the shooting tragedy in Orlando, and is intent on participating in the city's upcoming pride march.

Working together for years has turned Titus and Dan into great friends. But on their shift, they inevitably come across folks who are the victims of crimes perpetuated by those closest to them. It's on calls like these when they become more than just emergency medical technicians; they're also therapists and counselors, doing whatever they can to steer some troubled people back in the right direction.

Every night, the members of the Nightwatch in New Orleans are reminded in new ways to be thankful for what they have. This shift is no exception. EMT's Titus and Dan resuscitate an overdosing drug user just before all hope is lost; Brooke and Landon tend to a young girl with congenital heart issues; and a team of fire fighters contain a fire before it can wreak havoc. Then things get a little lighter when Titus and Dan learn a familiar patient is also a secret admirer of Holly.