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When Sherry Leighty goes missing in 1999, her family is left wondering how a dedicated mother of three could vanish without a trace. A decade later, the cold case heats up when Sherry's sister launches a social media campaign to help solve her sister's mysterious disappearance. An online tip unearths the killer truth and a sinister family secret. This episode features an interview with Shelly Leighty, who never gave up on solving her sister's case, along with rare home video of Sherry and her family not long before she disappeared.

When 25-year-old school teacher Christy Mirack is found brutally murdered in her Lancaster, Pennsylvania, apartment in 1992, there is no shortage of suspects. Frustration and fear mount as each person is ruled out, one by one, and eventually the case goes cold. Twenty-six years later, in 2018, cold case detectives get a break when a relative of the killer uploads DNA to a public genealogy website. This story features a rare interview with the victim's brother and the forensic genealogist who helped crack one of state's first cold cases to be solved by familial DNA technology.

In the heart of Cajun country, young mother Brenda DuPont is found murdered in her home in May 1988. The initial investigation sputters and turns cold, but Brenda's older sister Linda vows to solve Brenda's murder, no matter how long it takes.

When a deadly house fire claims the life of a family in rural Oklahoma, investigators suspect foul play and it sends a mother on a decades-long crusade to find out what happened to her missing teenage daughter and best friend.

In Wisconsin, advances in forensic clay modeling help investigators identify a murder victim whose skin was stripped from her head, neck, and legs. And in California, police track down two boys who enjoy satanic rituals and setting fires.

After 23 years, investigators finally track down the killers of an Atlanta policeman when the ex-wife of one of the killers phones in a tip; and a mother keeps the skeletal remains of the 3-year-old daughter she killed in a footlocker.

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A woman miraculously survives three gunshot wounds to the head. A family outing turns into a nightmare when they are attacked by bees. And a school library becomes a killing field as two gunmen go on a shooting rampage.

A convenience store worker plays dead to escape her abductor. An endurance athlete faces her greatest challenge ever after falling 60 feet in a remote canyon. A couple put their lives on the line to protect their children in a home invasion.

A man survives 23 hours in the ocean after he gets separated from his dive partner. A woman is robbed and threatened by her best friend and her brother. And, a woman is shot and blinded by a man who then holds her captive in his home.

A 16-year-old girl is abducted and assaulted by two gunmen. A deer hunter must drag himself up a dry creek bed for help after falling from a tree and breaking both his legs. A college student is used as a human shield when a gunman goes on a rampage in his school cafeteria.

Kelsey's family knew something was amiss when their usually responsible and responsive daughter didn't respond to their texts while out running an errand. Hear the harrowing saga around Kelsey's disappearance and how her parents' persistence with Kelsey's cell phone provider helped authorities find her.

When Deserae Turner didn't come home after school, her mother and friends began texting her incessantly. A massive search ensued, and 47 of her friends were questioned. Turns out her Snapchat may have been the key to the mystery.

When mother of two, Deanna Cook, missed her daily call to her mom, her family began to worry that Deanna's "stalker" may have had something to do with it. After texting and calling Deanna, her family called 911. But when their call fell on deaf ears, the family was forced to make a shocking discovery.

Rising social media Influencer Alexis Murphy was on her way to a hair appointment, but never arrived. When a photo of her abandoned car was posted on-line, her worried loved-ones knew something was terribly wrong. But there's finally a crack in the case when gas station surveillance video reveals something truly bizarre.

Iowa home-baker, Justina Rucinski, had just received an email with the largest cookie request of her career. But when the customer arrived at Justina's house to leave the deposit, Justina was brutally attacked and taken away at gunpoint. Justina's best friend, April, details the harrowing night of the attack that happened moments after she left Justina's home.

After 26-year-old rideshare driver Carolina Vargas drove a nice stranger to his hotel, she didn't have qualms about giving him another ride. But her trusting gesture turned tragic and Carolina was forced to fight for her life.

When retired rodeo champion Bob Huber takes a young, aspiring cowboy named Ryan Bryant under his wing, it seems like a perfect match. The two start running a business and coaching a little league team. Yet slowly but surely, one man begins to chafe under the yoke of their friendship and hatches a plan to rid himself of the other... forever. In a ruthless competition between the wily older man and the strong young buck, who will win?

Can guys and girls ever really be best friends? It's a question Alphonze Fitzhugh and Britani Coberly hear many times--and they always shrug it off. These Northern California teenagers are more like brother and sister, sharing a passion for sports and meeting up with their friends for bonfires in the local vineyards. But like a grape that isn't picked, this friendship withers on the vine. Hidden attraction turns into jealousy, which then sets off a chain reaction of anger and revenge.

Two best friends, steeped in the California "goth" culture are split apart by a dark, charismatic teen who holds sway over both of them. The teens' obsession with the dark side goes too far, and one of the BFFs is murdered in what police call a "senseless thrill kill."

Two girls in Pennsylvania grow up the best of friends, but things get rocky when they take the next step and become lovers. Add a third girl to the mix, and this relationship turns downright toxic. One of the girls ends up dead, and the other is sent to prison for the rest of her life.

A former deejay living in California, inherits money from his wealthy father. The heir's BFF, a banker, offers to help him manage the windfall, but the two have a falling out that ends up with a showdown, a murder and a manhunt.

Whoever said there's honor among thieves... never met this group of best friends. Michael Falco, Gary Evans, and Tim Rysedorph all come from working-class South Troy, NY. Friends since childhood, they dream of careers in music and the arts. But to survive in this Rust Belt town, they turn to small-time criminal activity. As the crimes get bigger, so do the stakes. The police are closing in, and one of them turns on his friends, murdering them one by one. Can he be stopped before he kills them all?