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He was from the wrong side of the tracks, she was the apple of her parents' eye and had every advantage in life. Together they became unlikely best friends, until another girl, and a secret, come between them.

At a school for at-risk youth in Illinois, Sarah Kolb rules the hallways. She takes new student Adrianne Reynolds under her wing, showing her the ropes and introducing her to the popular crowd.

Gerry Scotti and Barry Feldman are living the good life in Los Angeles. Gerry is a high-powered defense attorney, Barry his brilliant paralegal. They become best friends, each complementing the other's strengths and weaknesses.

In a sleepy Ohio town, two young girls find each other on line. Their friendship blossoms and then becomes something deeper. But when one of the girls hooks up with someone new, things take a dark turn and police have a murder to solve.

At the world's top university for the Deaf and hard of hearing, college freshmen Eric Plunkett and Joseph Mesa live across the hall from each other. Eric is an outgoing film buff with a preference for horror movies..

Michael Falco, Gary Evans, and Tim Rysedorph all come from working-class South Troy, NY. Friends since childhood, they dream of careers in music and the arts. But to survive in this Rust Belt town, they turn to small-time criminal activity.

Bridget Kelly is raped, shot three times, and left for dead by an intruder in her home. Daryl is caught in a freak blizzard that threatens to bury him alive in his jeep.

A heavily pregnant woman is brutally attacked by her neighbor. A young girl endures years of abuse by a family friend before being abducted and held captive for 104 days.

Three masked gunmen burst into Michelle's home, tape dynamite to the bodies of the bank executive and her 7-year-old daughter, and order her to rob the bank vault where she works.

Brandi and her friend, Liz, offer a ride to man who turns on them, stabbing Liz repeatedly and beating Brandi and then throwing her into a river.

In the city of New Orleans, police officers, fire fighters, and emergency medical technicians working the overnight shift answer as many as a thousand emergency calls every night.

It's the week of Mardi Gras and it's the busiest time of year for our first responders. Working the parade route comes with its own challenges and unique cases.

It's an emotional night on the Nightwatch in New Orleans as one EMS officer tells his partner that this is their last night on the job. Meanwhile, it's a tough night in a different way for the fire fighters as the group responds.

Working together for years has turned Titus and Dan into great friends. But on their shift, they inevitably come across folks who are the victims of crimes perpetuated by those closest to them.

Pierre and Jerry are backed up by Air Service when they go on a high-speed car chase through the streets of Tampa.

On Nightwatch not all tragedies are created equal and tonight, when the men and women serving New Orleans.

Every call on the Nightwatch can go in one of two directions. And when the calls come from every direction.

On the Nightwatch, you can't save everyone--but you try. New partners Tommy and Arkady join a desperate search for a victim who went under in the river; Holly and Nick rush a motorcyclist with devastating injuries to the hospital.

Police officers pursue suspected drug dealers, while Keeley saves a group of partiers from a violent schizophrenic.

If every night in New Orleans is an adventure, this one is filled with characters in situations unlike any other.

Family bonds and family struggles take center stage when a man approaches Robb and Bethany and asks them to help find his missing daughter whom he fears is dead.

As Titus puts it early in this episode, "When one of us gets hurt, we feel like all of us are hurt." And in New Orleans on the Nightwatch, every call isn't just about a victim whose life is in danger, or even a criminal who's broken the law.