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Can guys and girls ever really be best friends? It's a question Alphonze Fitzhugh and Britani Coberly hear many times--and they always shrug it off.

Lula Young and Linda Leedom seem like typical moms. They live on a quiet suburban street, raising their families. Through sickness and heartbreak, Lula and Linda are best friends and perfect neighbors. To make her dreams come true, one will do anything.

At the world's top university for the Deaf and hard of hearing, college freshmen Eric Plunkett and Joseph Mesa live across the hall from each other. Eric is an outgoing film buff with a preference for horror movies..

Any time best friends turn on each other, it's a tragedy--years of love and trust swept away in a moment of anger, jealousy, or greed. But some cases are so shocking that nobody sees them coming.

He was from the wrong side of the tracks, she was the apple of her parents' eye and had every advantage in life. Together they became unlikely best friends, until another girl, and a secret, come between them.

Dean Allen is a clean-cut carpenter in east Texas, a young man who always follows the rules. Dean befriends a newcomer, Robert Pogue, a butcher who never met a rule he couldn't break.

A machete-wielding intruder terrorizes a woman in her apartment; a savage attack by a grizzly bear leaves a man partially scalped and miles from help; and a blindfolded 16-year-old girl fights for her life after being abducted at knifepoint.

A woman miraculously survives three gunshot wounds to the head. A family outing turns into a nightmare when they are attacked by bees. And a school library becomes a killing field as two gunmen go on a shooting rampage.

A single mom is attacked by an old classmate after spurning his affections. A gold prospector survives five days in the Australian Outback. And a woman is left for dead after being carjacked then shot several times at close range.

Three masked gunmen burst into Michelle's home, tape dynamite to the bodies of the bank executive and her 7-year-old daughter, and order her to rob the bank vault where she works.

It's a full moon in New Orleans, and sure enough, all night long, the calls for the EMT's seem to get crazier and crazier: the victim of a machete hacking, the man whose finger is bitten off by a dog.

On the fourth of July in New Orleans, the heat seems to trigger havoc in the streets. Holly, Nick, and Keeley arrive at a bloody scene where a woman could lose her arm after a bar fight.

In a night filled with multiple shootings, Holly and Nick have to search for a gunshot victim that has gone missing.

Every night, the members of the Nightwatch in New Orleans are reminded in new ways to be thankful for what they have.

On Nightwatch not all tragedies are created equal and tonight, when the men and women serving New Orleans.

As Titus puts it early in this episode, "When one of us gets hurt, we feel like all of us are hurt." And in New Orleans on the Nightwatch, every call isn't just about a victim whose life is in danger, or even a criminal who's broken the law.

If every night in New Orleans is an adventure, this one is filled with characters in situations unlike any other.

As anyone in New Orleans could tell you, when times are toughest, family and friends are more important than anything in the world.

The EMT's recall and reflect on their craziest and most memorable calls on the Nightwatch shift in New Orleans.

The EMT's recall and reflect on their craziest and most memorable calls on the Nighwatch shift in New Orleans.

Officers Robb and Bethany are helped by the K9 Unit to corral a suspect who takes off running after a car chase.

Tampa first responders have a chaotic night treating seizure and overdose patients, while the ROC Squad Task Force tracks down suspected armed robbers in a high-speed chase.